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druckend nachweisen konnten, scheint

es für die Wirksamkeit von Vitamin C

und Vitamin E eine Kombination meh-

rere Ursachen zu geben. An einem stan-

dardisierten Mausmodell zur Induktion

einer neuropathischen Schmerzsympto-

matik zeigte sich, dass sowohl die Reak-

tion auf ROS wie auch die Modulation

der nozizeptiven Schmerzverarbeitung

und -weiterleitung durch die kombinier-

te Vitamingabe moduliert wird. Und

dies nicht nur peripher, sondern vor al-

lem auch auf Rückenmarksebene bezie-

hungsweise im dorsalen Hinterhorn. Die

Möglichkeit hierzu konnte in der Tat für

Vitamin C schon nachgewiesen werden,

da es auf spinaler wie auch auf zentraler

Ebene mit metatropen Glutamatrezepto-

ren interagiert [100].

Olaf Buchbinder

Schmerzzentrum

Geldern

An der Insel 15

47608 Geldern

Dr. Geert-Jan van Geffen

Radboud Universitair Medisch Centrum

Afdeling Anesthesiologie,

Pijn en Palliatieve Geneeskunde

NL-6500 HB Nijmegen

Prof. Dr. Gert Jan Scheffer

Radboud Universitair Medisch Centrum

Afdeling Anesthesiologie,

Pijn en Palliatieve Geneeskunde

NL-6500 HB Nijmegen

PD Dr. Hagen Maxeiner, D.E.S.A., E.D.I.C.

Universitätsklinikum Gießen und Marburg

Anaesthesiologie operative Intensiv­

medizin und Schmerztherapie

Rudolf-Buchheim-Straße 7, 35392 Gießen

Korrespondierender

Autor:

Prof. Dr. med. Jörg

Mühling, MBA

Radboud Universitair

Medisch Centrum

Afdeling Anesthesiologie,

Pijn en Palliatieve

Geneeskunde

Geert GrootepleinZuid 10

NL-6500 HB Nijmegen

E-Mail: jorg.muhling@

radboudumc.nl

Literatur

1.

Patrick N et al. Acute and chronic low back

pain. Med Clin North Am 2016;100(1):169–81

2.

Patrick N et al. Acute and chronic low back

pain. Med Clin North Am 2014;98(4):777–89

3. Jones LD et al. Back pain in the elderly: a

review. Maturitas 2014;78(4):258-62

4.

Nationale Versorgungsleitlinie Kreuz-

schmerz Langfassung. 1. Auflage, Version 5,

November 2010, AWMF-Register: nvl/007

5.

Airaksinen O et al. COST B13 Working Group

on Guidelines for Chronic Low Back Pain.

Chapter 4. European guidelines for the ma-

nagement of chronic nonspecific low back

pain. Eur Spine J 2006;15 Suppl 2:S192–300

6.

Kuss K et al. Activating therapy modalities

in older individuals with chronic non-specific low back pain: a systematic review.

Physiotherapy 2015;101(4):310–8

7.

Illés ST. [Low back pain: when and what to

do]. Orv Hetil 2015;156(33):1315–20 Review

Hungarian

8.

Kizhakkeveettil A et al. Integrative thera-

pies for low back pain that include comple-

mentary and alternative medicine care: a

systematic review. Glob Adv Health Med

2014;3(5):49–64

9.

Böger A. [Multimodal pain therapy in

chronic low back pain]. MMW Fortschr Med

2014;156 Spec no 2:73–6;

10. Hsu E, Murphy S, Chang D, Cohen SP. Expert

opinion on emerging drugs: chronic low

back pain. Expert Opin Emerg Drugs

2015;20(1):103–27

11. Veizi E, Hayek S. Interventional therapies for

chronic low back pain. Neuromodulation

2014;17 Suppl 2:31–45

12. Webster LR, Markman J. Medical manage-

ment of chronic low back pain: efficacy and

outcomes. Neuromodulation 2014;17 Suppl

2:18–23

13. Golob AL, Wipf JE. Low back pain. Med Clin

North Am 2014;98(3):405–28

14. Garg S et al. Web-Based Interventions for

Chronic Back Pain: A Systematic Review.

J Med Internet Res 2016;18(7):e139

15. Slade SC et al. Barriers to primary care

clinician adherence to clinical guidelines for

the management of low back pain: protocol

of a systematic review and meta-synthesis

of qualitative studies. BMJ Open 2015;5(4):

e007265

16. Steffens D et al. Prevention of Low Back

Pain: A Systematic Review and Meta-analysis. JAMA Intern Med 2016;176(2):199–

208

17. Hart A et al. The Role of Vitamin C in Ortho-

pedic Trauma and Bone Health. Am J

Orthop (Belle Mead NJ) 2015;44(7):306-11

18. Jacob RA, Sotoudeh G. Vitamin C function

and status in chronic disease. Nutr Clin Care

2002;5(2):66–74

19. Frei B et al. Ascorbate is an outstanding

antioxidant in human blood plasma. Proc

Natl Acad Sci USA 1989;86(16):6377–81

20. Monsen ER. Dietary reference intakes for

the antioxidant nutrients: vitamin C,

vitamin E, selenium, and carotenoids. J Am

Diet Assoc 2000;100(6): 637–40

21. Padh H. Vitamin C: newer insights into its

biochemical functions. Nutr Rev 1991;49(3):

65–70

22. Gershoff SN. Vitamin C (ascorbic acid): new

roles, new requirements? Nutr Rev 1993;

51(11):313–26

23. Li Y, Schellhorn HE. New developments and

novel therapeutic perspectives for vitamin

C. J Nutr

2007;137(10):2171–

84

24. Szent-Györgyi A. On the function of hexu-

ronic acid in the respiration of the cabbage

leaf. J Biol Chem 1931;90(1):385–93

25. Svirbely JL, Szent-Györgyi A. The chemical

nature of vitamin C. Biochem J 1933;27(1):

279–85

26. Pauling L. Vitamin C and the Common Cold.

Freeman, San Francisco; 1970

27. Spittle CR. Atherosclerosis and vitamin C.

Lancet 1971;2(7737):1280–81

28. Chappell LC et al. Effect of antioxidants on

the occurrence of pre-eclampsia in women

at increased risk: a randomised trial. Lancet

1999;354(9181):810–16

29. Block G. Vitamin C and cancer prevention:

the epidemiologic evidence. Am J Clin Nutr

1991;53(1 suppl):270S–282S.

30. Creagan ET et al. Failure of high-dose

vitamin C (ascorbic acid) therapy to benefit

patients with advanced cancer. A cont-

rolled trial. N Engl J Med 1979;301(13):687–

90

31. Hemila H, Chalker E. Vitamin C for

preventing and treating the common cold.

Cochrane Database Syst Rev 2013;1:

CD000980

32. Poston L et al. Vitamins in Pre-eclampsia

(VIP) Trial Consortium. Vitamin C and vitamin

E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-

controlled trial. Lancet 2006;367(9517):1145–

54

33. Roberts JM et al; Eunice Kennedy Shriver

National Institute of Child Health and Hu-

man Development Maternal-Fetal Medicine

Units Network. Vitamins C and E to prevent

complications of pregnancy associated

hypertension. N Engl J Med 2010;362(14):

1282–91

34. Levine M et al. Vitamin C: a concentration-

function approach yields pharmacology

and therapeutic discoveries. Adv Nutr 2011;

2(2):78–88

35. Levine Met al. Criteria and recommen­

dations for vitamin C intake. JAMA 1999;

281(15):1415–23

36. Glatthaar BE et al. The role of ascorbic acid

in carcinogenesis. Adv Exp Med Biol 1986;

206:357–77

37. Carpenter KJ. The History of Scurvy and

Vitamin C. Cambridge University Press New

York; 1986

38. Murad S et al. Regulation of collagen

synthesis by ascorbic acid. Proc Natl Acad

Sci USA 1981;78(5):2879–82

39. Leonard BE. Pain, Depression and Inflam-

mation: Are Interconnected Causative

Factors Involved? Mod Trends Pharmaco-

psychiatri 2015;30:22–35

40. Muley MM et al. Preclinical Assessment of

Inflammatory Pain. CNS Neurosci Ther 2016;

22(2):88-101

41. Dionne CE et al. Serum vitamin C and spinal

pain: a nationwide study. Pain 2016 Jul 18

42. Finck H et al. Cross-sectional and prospecti-

ve associations between dietary and plas-

Schmerzmedizin 2017; 33 (1)

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